As the U.S. and other countries went into lockdown, saving lives from COVID-19 was the main priority. Many people reacted by buying alcohol to drink at home while in isolation. Now, as lockdown ends, we are likely to see the impact of alcohol’s harm. Two groups especially need our attention: those already struggling with alcohol dependence and those close to becoming dependent on alcohol during lockdown. For them, dependence will be triggered by sadness about a loss, job insecurity, or troubled relationships. Alcohol is strongly associated with domestic violence, and we know that there was an increase in the number of calls to domestic violence organizations during lockdown. We all must be prepared to support and help going forward.